HLA-DRB1 in eight Finnish monozygotic twin pairs concordant for rheumatoid arthritis
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HLA-DRB1 in eight Finnish monozygotic twin pairs concordant for rheumatoid arthritis.
This study presents the results of HLA-DRB1 typing of the eight monozygotic twin pairs with both members affected by rheumatoid arthritis (RA), sampled in the nationwide Finnish twin cohort. The shared epitope, associated with RA in case-control studies, was present in all eight twin pairs, being significantly more frequent than among RA patients in a recent Dutch case-control study. Furthermor...
متن کاملRelative importance of genetic effects in rheumatoid arthritis: historical cohort study of Danish nationwide twin population.
OBJECTIVE To determine the relative importance of environmental and genetic effects in the development of rheumatoid arthritis. DESIGN Historical cohort study with record linkage between a twin registry and the Danish discharge registry as well as the Danish national registry of deaths used to estimate completeness. SETTING Two population based nationwide twin birth cohorts. PARTICIPANTS ...
متن کاملHLA-DR-DQ haplotypes and genotypes in Finnish patients with rheumatoid arthritis.
OBJECTIVES To elucidate the contribution of HLA-DR-DQ haplotypes and their genotypic combinations to susceptibility to rheumatoid arthritis, and to evaluate the various models for HLA associated risk for the disease in a series of Finnish patients. METHODS 322 Finnish patients with rheumatoid arthritis were typed for common north European HLA-DR-DQ haplotypes and compared with a series of 124...
متن کاملGene Repertoire is Genetically Controlled and Unaltered by Chronic Autoimmune Stimulation
The factors controlling immunoglobulin (Ig) gene repertoire formation are poorly understood. Studies on monozygotic twins have helped discern the contributions of genetic versus environmental factors on expressed traits. In the present experiments, we applied a novel anchored PCR-ELISA system to compare the heavy chain V gene (V H ) subgroup repertoires of m and g expressing B lymphocytes from ...
متن کاملX chromosome inactivation patterns correlate with fetal-placental anatomy in monozygotic twin pairs: implications for immune relatedness and concordance for autoimmunity.
BACKGROUND Monozygotic (MZ) twinning is a poorly understood phenomenon that may result in subtle biologic differences between twins, despite their identical inheritance. These differences may in part account for discordant expression of disease in MZ twin pairs. Due to their stochastic nature, differences in X chromosome inactivation patterns are one source of such variation in female MZ twins....
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